2.8.2020 THE END OF ALZHEIMER'S - THE FIRST PROGRAM TO PREVENT and REVERSE COGNITIVE DECLINE By Dale E. Bredesen, MD

PART ONE - The Alzhemer's Solution

CHAPTER 1 - Disrupting Dementia

*7 ...in the  past targeting amyloid  was supposed to be the golden ticket to curing Alzheimer's. it wasn't.

*9  ...(different thought-to-be cures are not...also...
'Alzheimer's is Not a single disease. sure, the symptoms might make it look like it is, but ...we discovered that there are three main subtypes of Alzheimer's.Our research on the different biochemical profiles of people  with Alz's has made it clear that these three readily distinguishable subtypes are each driven  by different biochemical processes. Each one require a different treatment...

*10  Alz disease can be prevented and in many cases its associated cognitive decline can be reversed...in my lab..culminated in the first reversals of cognitive decline in early Alzheimer's disease ) MCI (mild cognitive impairment) and SCI (subjective cognitive impairment) and its precursors, (def - something that precedes.
*11 ApoE4 (is short for apolipoprotein E;  an apolipoprotein is a protein that carries lipids  - ie. fats)is the strongest known genetic risk factor. Carrying one ApoE4 (that is, inherited from one parent) increases your lifetime risk of Alz to 30%, while carrying two  copies (inheriting copies from both parents) increases it to well over  50% (from 50 to 90% depending on which study you read)

*12 ...there is a program that can reduce the risk
*13  ...the first ever scientific publication of a study, in  2014,  reporting the reversal of cognitive decline in  patients...with Alz.. or its precursors, thanks to sophisticated personalized protocol based on our... research on the neurobiology of Alz..Called ReCODE, for reversal of cognitive decline, the protocol not only achieved the reversal...in Alz and pre-Alz..but allowed patients to sustain that improvement.
*16  ...these discoveries show... that this devastating disease is the result of normal, healthy brain process that has gone haywire. That is , the brain suffers some injury, infection, or other assault...and responds by defending itself. the defense mechanism includes producing the Alz's-associated amyloid. Yes...the very amyloid that everyone has been trying to get rid of, is part of a PROTECTIVE response.
...In chapter 7,  you'll learn about the tests that identify what is causing your cognitive decline or putting you at risk for it -who you may already be giving yourself Alz...The tests are necessary because the often numerous contributors to one person's cognitive decline or putting you at risk for it -how you may already be giving yourself Alz..the tests are necessary because the often numerous contributors to one person's cognitive decline are very likely different from the contributors to someone else's. these tests therefore give you a

*17  personalized risk profile, letting you know which factors to address to optimize improvement.
You will learn the rationale behind each test -  that is, how the physiological parameter it evaluates contributes to brain function and Alz...   Chapter 7 summarizes the tests involved in this 'cognoscopy' and explains the guiding  principles behind them.
Chapters 8-9 explain what to do in response to the test results. These discuss the fundamentals that must be addressed in order to reverse cognitive decline and reduce risk of future decline:
inflammation
infection
insulin resistance
hormone and supportive nutrient depletion
toxin exposure and
of lost or dysfunctional brain connections(synapses).
the replacement and protection of lost or dysfunctional brain connections (synapses)
this is not a 'one size fits all' approach.
everyone's version of ReCODE is personalized, based on their test results:
your version will be different fro that of others because it is optimized to your unique physiology...

in chapters 10-12, I explain the keys to achieving the very best results and to sustaining that improvement.  These chapters offer workarounds,not only to help you succeed in reversing cognitive decline, but also to address the questions and criticism that have been directed at this approach.

Since the advent of'modern' medicine in the nineteenth century, physicians have been trained to diagnose disease- for example, hypertenion or congestive heart failure or arthritis -and prescribes standard one-size-fits-all  treatment, such as an antihypertensive for hypertension.that is slowly changing, as with precision cancer



 in Chapter 10-12, I explain the keys to achieving the very best results and o sustaining that improvement. These chapters offer workarounds, not only to help you succeed in reversing cognitive  decline, but also to address the questions and criticism that have been directed at this approach.
Since the advent of'modern' medicine in the nineteenth century, physicians have been trained to diagnose disease - for example, hypertension or congestive heart failure or arthritis - and prescribe  a standard one-size-fits-all  treatment, such as an antihypertensive for hypertension. That is slowly changing, as with precision cancer treatments in which the genetic profile of a patient's tumor dictates what drug to prescribe. The push for personalized medicine could bring us closer to